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Research Articles (Nagaraja, V.)

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Mycobacterium tuberculosis Rho Is an NTPase with Distinct Kinetic Properties and a Novel RNA-Binding Subdomain

Mitra, Anirban; Misquitta, Rachel; Nagaraja, V. (Public Library of Science, 2014)

Two mechanisms - factor independent and dependent termination - ensure the completion of RNA synthesis in eubacteria. Factor-dependent mechanism relies on the Rho protein to terminate transcription by interacting with RNA ...
Conditional silencing of topoisomerase I gene of Mycobacterium tuberculosis validates its essentiality for cell survival

Ahmed, Wareed; Menon, Shruti; Godbole, Adwait Anand; Karthik, Pullela V. D. N. B.; Nagaraja, V. (Oxford University Press, 2014)

Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic ...
Direct regulation of topoisomerase activity by a nucleoid-associated protein

Ghosh, Soumitra; Mallick, Bratati; Nagaraja, V. (Oxford University Press, 2014)

The topological homeostasis of bacterial chromosomes is maintained by the balance between compaction and the topological organization of genomes. Two classes of proteins play major roles in chromosome organization: the ...
Molecular Basis for the Differential Quinolone Susceptibility of Mycobacterial DNA Gyrase

Kumar, Rupesh; Madhumathi, Bhavani Shankar; Nagaraja, V. (American Society Microbiology, 2014)

DNA gyrase is a type II topoisomerase that catalyzes the introduction of negative supercoils in the genomes of eubacteria. Fluoroquinolones (FQs), successful as drugs clinically, target the enzyme to trap the gyrase-DNA ...
Allosteric Transition Induced by Mg2+ Ion in a Transactivator Monitored by SERS

Kundu, Partha P.; Bhowmick, Tuhin; Swapna, Ganduri; Kumar, G. V. Pavan; Nagaraja, V.; Narayana, Chandrabhas (American Chemical Society, 2014)

We demonstrate the utility of the surface-enhanced Raman spectroscopy (SERS) to monitor conformational transitions in protein upon ligand binding. The changes in protein's secondary and tertiary structures were monitored ...
Inhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poison

Godbole, Adwait Anand; Ahmed, Wareed; Bhat, Rajeshwari Subray; Bradley, Erin K.; Ekins, Sean; Nagaraja, V. (Academic Press Inc Elsevier Science, 2014)

m-AMSA, an established inhibitor of eukaryotic type II topoisomerases, exerts its cidal effect by binding to the enzyme-DNA complex thus inhibiting the DNA religation step. The molecule and its analogues have been successfully ...
Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors

Bhowmick, Tuhin; Ghosh, Soumitra; Dixit, Karuna; Ganesan, Varsha; Ramagopal, Udupi A.; Dey, Debayan; Sarma, Siddhartha P.; Ramakumar, Suryanarayanarao; Nagaraja, V. (Nature Publishing Group, 2014)

The nucleoid-associated protein HU plays an important role in maintenance of chromosomal architecture and in global regulation of DNA transactions in bacteria. Although HU is essential for growth in Mycobacterium tuberculosis ...
Autoregulation of topoisomerase I expression by supercoiling sensitive transcription

Ahmed, Wareed; Menon, Shruti; Karthik, Pullela V. D. N. B.; Nagaraja, Valakunja (Oxford University Press, 2016)

The opposing catalytic activities of topoisomerase I (TopoI/relaxase) and DNA gyrase (supercoiling enzyme) ensure homeostatic maintenance of bacterial chromosome supercoiling. Earlier studies in Es-cherichia coli suggested ...
ZCF32, a fungus specific Zn(II)2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans

Kakade, Pallavi; Sadhale, Parag; Sanyal, Kaustuv; Nagaraja, Valakunja (Nature Publishing Group, 2016)

As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ...

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