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The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat

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dc.contributor.author Aralaguppe, Shambhu Prasad G.
dc.contributor.author Sharma, Shilpee
dc.contributor.author Menon, Malini
dc.contributor.author Prasad, Vinayaka R.
dc.contributor.author Saravanan, Shanmugam
dc.contributor.author Murugavel, Kailapuri G.
dc.contributor.author Solomon, Suniti
dc.contributor.author Ranga, Udaykumar
dc.date.accessioned 2017-01-24T06:33:21Z
dc.date.available 2017-01-24T06:33:21Z
dc.date.issued 2016
dc.identifier.citation Aralaguppe, S. P. G.; Sharma, S.; Menon, M.; Prasad, V. R.; Saravanan, S.; Murugavel, K. G.; Solomon, S.; Ranga, U., The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat. Aids Research and Human Retroviruses 2016, 32 (5), 503-514 http://dx.doi.org/10.1089/aid.2015.0208 en_US
dc.identifier.citation AIDS Research and Human Retroviruses en_US
dc.identifier.citation 32 en_US
dc.identifier.citation 5 en_US
dc.identifier.issn 0889-2229
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2193
dc.description Restricted Access en_US
dc.description.abstract Using several HIV-1 tat exon 1 amino acid sequences available from public databases and additional sequences derived from a southern Indian clinical cohort, we compared the profile of the signature amino acid residues (SAR) between two different time periods, 1986-2004 and 2005-2014. The analysis identified eight positions as signature residues in subtype C Tat and demonstrated a changing pattern at four of these positions between the two periods. At three locations (histidine 29, serine 57, and proline 60), there appears to be a nonuniform negative selection against the SAR. The negative selection appears to be severe, especially against histidine 29 (p<.0001) and moderate against proline 60 (p<.0001). The negative selection against serine 57 is statistically insignificant and appears to have begun recently. At position 63, the frequency of signature residue glutamic acid increased over the past decade, although the difference was not significant. Importantly, at the three locations where the negative selection is in progress, the substitute amino acids are the generic residues present in most of the other HIV-1 subtypes. Our data demonstrate that viral evolution can subject specific amino acid residues to subtle and progressive selection pressures without affecting the prevalence of other amino acid residues. en_US
dc.description.uri 1931-8405 en_US
dc.description.uri http://dx.doi.org/10.1089/aid.2015.0208 en_US
dc.language.iso English en_US
dc.publisher Mary Ann Liebert, Inc en_US
dc.rights @Mary Ann Liebert, Inc, 2016 en_US
dc.subject Immunology en_US
dc.subject Infectious Diseases en_US
dc.subject Virology en_US
dc.subject Human-Immunodeficiency-Virus en_US
dc.subject Clade-Specific Differences en_US
dc.subject Metal-Linked Dimer en_US
dc.subject Protein en_US
dc.subject Type-1 en_US
dc.subject Sequences en_US
dc.subject Transactivator en_US
dc.subject Transcription en_US
dc.subject Monocytes en_US
dc.subject Motif en_US
dc.title The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat en_US
dc.type Article en_US


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