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Nanoarchitectonics of Small Molecule and DNA for Ultrasensitive Detection of Mercury

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dc.contributor.author Pandeeswar, M.
dc.contributor.author Senanayak, Satyaprasad P.
dc.contributor.author Govindaraju, T.
dc.date.accessioned 2017-01-24T06:35:04Z
dc.date.available 2017-01-24T06:35:04Z
dc.date.issued 2016
dc.identifier.citation Pandeeswar, M.; Senanayak, S. P.; Govindaraju, T., Nanoarchitectonics of Small Molecule and DNA for Ultrasensitive Detection of Mercury. Acs Applied Materials & Interfaces 2016, 8 (44), 30362-30371 http://dx.doi.org/10.1021/acsami.6b10527 en_US
dc.identifier.citation ACS Applied Materials & Interfaces en_US
dc.identifier.citation 8 en_US
dc.identifier.citation 44 en_US
dc.identifier.issn 1944-8244
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2198
dc.description Open Access (Manuscript) en_US
dc.description.abstract Reliable and ultrasensitive detection of mercury ions is of paramount importance for toxicology assessment, environmental protection, and human health. Herein, we present a novel optoelectronic approach based on nano architectonics of small-molecule templated DNA system that consists of an adenine (A)-conjugated small organic semiconductor (BNA) and deoxyribo-oligothymidine (dT(n)). This mutually templated dynamic chiral coassembly system (BNAn-dT(n)) with tunable chiroptical, morphological, and electrical properties is tapped in to enable ultrasensitive and selective detection of inorganic and organometallic mercury in water. We observe a rapid transformation of the BNA(n)-dT(n) coassembly into a metallo-DNA duplex [dT-Hg-dT](n), in the presence of mercury, which is utilized for a chiro-optical and conductivity-based rapid and subnanomolar sensitivity (>= 0.1 nM, 0.02 ppb) to mercury ions in water (similar to 100 times lower than United States Environmental Protection Agency tolerance limit). This ultrasensitive detection of inorganic and organometallic mercury is driven by a novel chemical design principle that allows strong mercury thymine interaction. This study is anticipated to inspire the development of future templated DNA nanotechnology-based optoelectronic devices for the rapid and ultrasensitive detection of numerous other toxic analytes. en_US
dc.description.uri http://dx.doi.org/10.1021/acsami.6b10527 en_US
dc.language.iso English en_US
dc.publisher American Chemical Society en_US
dc.rights @American Chemical Society, 2016 en_US
dc.subject Materials Science en_US
dc.subject environmental pollutant en_US
dc.subject ultra sensitive detection of mercury en_US
dc.subject small organic semiconductor-DNA nanoarchitectonics en_US
dc.subject chiroptical and electrical detection en_US
dc.subject Functionalized Gold Nanoparticles en_US
dc.subject Colorimetric Detection en_US
dc.subject Selective Recognition en_US
dc.subject Room-Temperature en_US
dc.subject Aqueous-Media en_US
dc.subject One-Step en_US
dc.subject Hg Ii en_US
dc.subject Ions en_US
dc.subject Water en_US
dc.subject Fluorescence en_US
dc.title Nanoarchitectonics of Small Molecule and DNA for Ultrasensitive Detection of Mercury en_US
dc.type Article en_US


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