Small molecular adjuvantsto repurpose and rehabilitate obsolete antibiotics against multidrug-resistant bacteria

Abstract

Antibiotic resistance-global threat and need Infectious diseases continue to wreak havoc globally and are the biggest threat for public health worldwide.1 They cause nearly 15 million global deaths every year.1, 2 Antimicrobial resistance (AMR) has further aggravated the problem. According to the review on antimicrobial resistance commissioned by Jim O’ Neill in 2014, about 0.7 million deaths are caused by AMR annually and this number is expected to increase to 10 million by 2050.3 If this problem is left unchecked, global healthcare costs are expected to increase to $100 trillion by 2050