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On the Sequence of Reactions Leading to Cytochrome P-450 Synthesis-Effect of Drugs

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dc.contributor.author Rajamanickam, Chellam
dc.contributor.author Rao, M R S
dc.contributor.author Padmanaban, Govindarajan
dc.date.accessioned 2012-02-09T10:55:16Z
dc.date.available 2012-02-09T10:55:16Z
dc.date.issued 1975
dc.identifier 0021-9258 en_US
dc.identifier.citation Journal of Biological Chemistry 250(6), 2305-2310 (1975) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/364
dc.description Restricted Access en_US
dc.description.abstract The effect of phenobarbital on the rates of the synthesis of the protein and heme moieties of cytochrome P-450 has been studied. For this purpose, cytochrome P-450 has been partially purified as its P-420 derivative and the labeled amino acid incorporation into the protein has been studied after subjecting a partially purified preparation to sodium dodecyl sulfate gel electrophoresis. The incorporation studies into the protein species after sodium dodecyl sulfate gel electrophoresis reveal that the drug primarily accelerates the rate of apoprotein synthesis followed by an increase in the rate of heme synthesis. The messenger for apocytochrome P-450 appears to be fairly stable. en_US
dc.description.uri http://www.jbc.org/content/250/6/2305.abstract en_US
dc.description.uri http://www.jbc.org/content/250/6/2305.full.pdf+html en_US
dc.language.iso en en_US
dc.publisher The American Society for Biochemistry and Molecular Biology Inc en_US
dc.rights © 1975 The American Society for Biochemistry and Molecular Biology Inc en_US
dc.subject 5-Aminolevulinate Synthetase-metabolism en_US
dc.subject Allylisopropylacetamide -pharmacology en_US
dc.subject Animals en_US
dc.subject Apoproteins - biosynthesis en_US
dc.subject Cycloheximide - pharmacology en_US
dc.subject Cytochrome P-450 Enzyme System - biosynthesis en_US
dc.subject Dactinomycin - pharmacology en_US
dc.subject Endoplasmic Reticulum - metabolism en_US
dc.subject Glycine - metabolism en_US
dc.subject Heme - biosynthesis en_US
dc.subject Iron - metabolism en_US
dc.subject Liver - drug effects en_US
dc.subject metabolism en_US
dc.subject Male en_US
dc.subject Microsomes en_US
dc.subject Liver - metabolism en_US
dc.subject Phenobarbital - pharmacology en_US
dc.subject Rats en_US
dc.title On the Sequence of Reactions Leading to Cytochrome P-450 Synthesis-Effect of Drugs en_US
dc.type Article en_US


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