dc.contributor.author | Rajamanickam, Chellam | |
dc.contributor.author | Rao, M R S | |
dc.contributor.author | Padmanaban, Govindarajan | |
dc.date.accessioned | 2012-02-09T10:55:16Z | |
dc.date.available | 2012-02-09T10:55:16Z | |
dc.date.issued | 1975 | |
dc.identifier | 0021-9258 | en_US |
dc.identifier.citation | Journal of Biological Chemistry 250(6), 2305-2310 (1975) | en_US |
dc.identifier.uri | https://libjncir.jncasr.ac.in/xmlui/10572/364 | |
dc.description | Restricted Access | en_US |
dc.description.abstract | The effect of phenobarbital on the rates of the synthesis of the protein and heme moieties of cytochrome P-450 has been studied. For this purpose, cytochrome P-450 has been partially purified as its P-420 derivative and the labeled amino acid incorporation into the protein has been studied after subjecting a partially purified preparation to sodium dodecyl sulfate gel electrophoresis. The incorporation studies into the protein species after sodium dodecyl sulfate gel electrophoresis reveal that the drug primarily accelerates the rate of apoprotein synthesis followed by an increase in the rate of heme synthesis. The messenger for apocytochrome P-450 appears to be fairly stable. | en_US |
dc.description.uri | http://www.jbc.org/content/250/6/2305.abstract | en_US |
dc.description.uri | http://www.jbc.org/content/250/6/2305.full.pdf+html | en_US |
dc.language.iso | en | en_US |
dc.publisher | The American Society for Biochemistry and Molecular Biology Inc | en_US |
dc.rights | © 1975 The American Society for Biochemistry and Molecular Biology Inc | en_US |
dc.subject | 5-Aminolevulinate Synthetase-metabolism | en_US |
dc.subject | Allylisopropylacetamide -pharmacology | en_US |
dc.subject | Animals | en_US |
dc.subject | Apoproteins - biosynthesis | en_US |
dc.subject | Cycloheximide - pharmacology | en_US |
dc.subject | Cytochrome P-450 Enzyme System - biosynthesis | en_US |
dc.subject | Dactinomycin - pharmacology | en_US |
dc.subject | Endoplasmic Reticulum - metabolism | en_US |
dc.subject | Glycine - metabolism | en_US |
dc.subject | Heme - biosynthesis | en_US |
dc.subject | Iron - metabolism | en_US |
dc.subject | Liver - drug effects | en_US |
dc.subject | metabolism | en_US |
dc.subject | Male | en_US |
dc.subject | Microsomes | en_US |
dc.subject | Liver - metabolism | en_US |
dc.subject | Phenobarbital - pharmacology | en_US |
dc.subject | Rats | en_US |
dc.title | On the Sequence of Reactions Leading to Cytochrome P-450 Synthesis-Effect of Drugs | en_US |
dc.type | Article | en_US |