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Biochemical Effects of the Porphyrinogenic Drug Allyisopropylacetamide

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dc.contributor.author Rao, M R S
dc.contributor.author Padmanaban, Govindarajan
dc.date.accessioned 2012-02-22T11:32:12Z
dc.date.available 2012-02-22T11:32:12Z
dc.date.issued 1973
dc.identifier.citation Biochemical Journal 134(4), 859-868 (1973) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/494
dc.description Restricted Access en_US
dc.description.abstract Successive administrations of allylisopropylacetamide, a potent porphyrinogenic drug, increase liver weight, microsomal protein and phospholipid contents. There is an increase in the rate of microsomal protein synthesis in vivo and in vitro. The drug decreases microsomal ribonuclease activity and increases NADPH-cytochrome c reductase activity. Phenobarbital, which has been reported to exhibit all these changes mentioned, is a weaker inducer of delta-aminolaevulinate synthetase and increases the rate of haem synthesis only after a considerable time-lag in fed female rats, when compared with the effects observed with allylisopropylacetamide. Again, phenobarbital does not share the property of allylisopropylacetamide in causing an initial decrease in cytochrome P-450 content. Haematin does not counteract most of the biochemical effects caused by allylisopropylacetamide, although it is quite effective in the case of phenobarbital. Haematin does not inhibit the uptake of [2-(14)C]allylisopropylacetamide by any of the liver subcellular fractions. en_US
dc.description.uri http://www.ncbi.nlm.nih.gov/pubmed/4357714 en_US
dc.description.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177893/?tool=pubmed en_US
dc.language.iso en en_US
dc.publisher Portland Press en_US
dc.rights © 1973 The Biochemical Society en_US
dc.subject Acetamides - pharmacology en_US
dc.subject Allylisopropylacetamide - pharmacology en_US
dc.subject Animals en_US
dc.subject Carbon Radioisotopes en_US
dc.subject Cytochrome P-450 Enzyme System - analysis en_US
dc.subject Cytochrome Reductases - analysis en_US
dc.subject Cytochrome c Group - analysis en_US
dc.subject Female en_US
dc.subject Heme - biosynthesis en_US
dc.subject Liver - drug effects en_US
dc.subject Microsomes en_US
dc.subject Liver - analysis en_US
dc.subject Microsomes en_US
dc.subject Liver - drug effects en_US
dc.subject Organ Size en_US
dc.subject Phenobarbital - pharmacology en_US
dc.subject Phospholipids - analysis en_US
dc.subject Proteins - analysis en_US
dc.subject RNA - analysis en_US
dc.subject Rats en_US
dc.subject Ribonucleases - analysis en_US
dc.title Biochemical Effects of the Porphyrinogenic Drug Allyisopropylacetamide en_US
dc.type Article en_US


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