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Effect of Hexachlorobenzene on Haem Synthesis

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dc.contributor.author Rajamanickam, Chellam
dc.contributor.author Amrutavalli, J
dc.contributor.author Rao, M R S
dc.contributor.author Padmanaban, G
dc.date.accessioned 2012-02-28T09:12:56Z
dc.date.available 2012-02-28T09:12:56Z
dc.date.issued 1972
dc.identifier 0264-6021 en_US
dc.identifier.citation Biochemical Journal 129(2), 381-7 (1972) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/510
dc.description Restricted Access en_US
dc.description.abstract Several drugs are known to induce the liver microsomal mixed-function oxidase system when administered in vivo or even in vitro in cell culture. A sequence of events has been suggested in which the drug is visualized to induce delta-aminolaevulinate synthetase, the first and rate-limiting enzyme of the haem-biosynthetic pathway, which is followed by enhanced haem synthesis and cytochrome P-450 content, facilitating the increase in the drug-metabolizing activity of the liver microsomal fraction. The present studies show that the fungicide hexachlorobenzene, when administered to female rats, can lead to enhanced amounts and rate of synthesis of cytochrome P-450 under conditions when the rate of total haem synthesis has not appreciably altered. The subsequent increase in the rate of total haem synthesis as well as the initial increase in amounts of cytochrome P-450 are brought about under conditions when delta-aminolaevulinate synthetase activity remains constant. However, manifestation of porphyria due to prolonged drug administration is accompanied by a twofold increase in delta-aminolaevulinate synthetase activity. The increase in enzyme activity appears to be due to a decreased degradation rate of the enzyme. en_US
dc.description.uri http://www.ncbi.nlm.nih.gov/pubmed/4643324 en_US
dc.description.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174088/?tool=pubmed en_US
dc.language.iso en en_US
dc.publisher The Biochemical Society (Portland Press) en_US
dc.rights © 1972 The Biochemical Society en_US
dc.subject 5-Aminolevulinate Synthetase - metabolism en_US
dc.subject Amino Acids - metabolism en_US
dc.subject Animals en_US
dc.subject Benzene Derivatives en_US
dc.subject Cells en_US
dc.subject Cultured en_US
dc.subject Chlorine en_US
dc.subject Cytochrome P-450 Enzyme System - metabolism en_US
dc.subject Enzyme Induction en_US
dc.subject Female en_US
dc.subject Half-Life en_US
dc.subject Heme - biosynthesis en_US
dc.subject Insecticides en_US
dc.subject Liver - drug effects en_US
dc.subject Microsomes en_US
dc.subject Liver - drug effects en_US
dc.subject enzymology en_US
dc.subject Organ Size en_US
dc.subject Plants en_US
dc.subject Porphobilinogen - metabolism en_US
dc.subject Porphyrias - chemically induced en_US
dc.subject Porphyrins - metabolism en_US
dc.subject Rats en_US
dc.title Effect of Hexachlorobenzene on Haem Synthesis en_US
dc.type Article en_US


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