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Title: The Relationship between Delta-Aminolaevulinate Synthetase Induction and the Concentrations of Cytochrome P-450 and Catalase in Rat Liver
Authors: Rao, M R S
Malathi, K
Padmanaban, G
Keywords: 5-Aminolevulinate Synthetase - biosynthesis
Amides - pharmacology
Bilirubin - pharmacology
Catalase - biosynthesis
Cycloheximide - pharmacology
Cytochrome P-450 Enzyme System - biosynthesis
Enzyme Induction
Glucose - pharmacology
Heme - pharmacology
Liver - enzymology
Liver - metabolism
Phenobarbital - pharmacology
Porphyrins - metabolism
Proadifen - pharmacology
Issue Date: 1972
Publisher: The Biochemical Society
Citation: Biochemical Journal 127(3), 553-559 (1972)
Abstract: The porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction of δ-aminolaevulinate synthetase and the consequent overproduction of haem. The allylisopropylacetamide-mediated breakdown of cytochrome P-450 is a rapid event and has a reciprocal relationship to the pattern of δ-aminolaevulinate synthetase induction. Breakdown of cytochrome P-450 appears to be one of the conditions leading to the `derepression' of δ-aminolaevulinate synthetase.
Description: Restricted Access
Other Identifiers: 0264-6021
Appears in Collections:Research Papers (M.R.S. Rao)

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