Abstract:
Cell cycle is a set of intricate events that lead to the exact duplication of a cell into
two daughter cells and its existence is vital for the propagation of life. To ensure the fidelity
of this life preserving process, there are certain guards assigned at each gate. As one event
leads to another, certain kinases that come under “cell cycle core kinases” act as engines to
propagate the cell from one phase to another whereas a group of proteins clubbed together as
“checkpoint proteins”, ensure the integrity of the previous event (Fig.1) [1]. Cell cycle is divided into two major phases: Interphase and M phase, of which, the
interphase is further divided into G1, S and G2 phases. The cell ensures that no event is
repeated or bypassed with the help of cyclins and cyclin dependent kinases. These come
under the category of “core cell cycle kinases”. Each phase/event is controlled by a specific
cyclin /CDK complex that is present during that particular phase but gets degraded
immediately after the completion of the phase. There are a set of checkpoint proteins at the entrance and exit of each phase .Such proteins are called checkpoint proteins and Aurora
kinase A and B come under this class of mitotic kinases.
