This chapter gives an introduction on Plasmodium falciparum life cycle and its metabolism. Studying P. falciparum metabolism will not only lead to novel biochemical targets for chemotherapeutic intervention but also ...

"Stem cells are unspecialized cells of embryonic, fetal or adult origin, which can give rise to the differentiated and mature cell types in the organism. Their potency to differentiate into different cell types depends ...

Abstract not available

Macroautophagy (herein autophagy) is a cellular catabolic pathway in which cytoplasmic components are captured by vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Autophagy occurs in ...

Man and malaria seem to have evolved together. The origin of malaria parasites can be traced along with the history of mankind. Malaria parasites probably originated in Africa and fossils mosquitoes have been found up ...

Allostery refers to a phenomenon wherein binding of a ligand molecule at a site distinct from the active site brings about changes at the active site. Allostery may reveal itself as either inhibition or activation of the ...

The precise transmission of the genetic information from one generation to the next during the mitotic cell cycle is extremely important for a eukaryotic organism. This process involves faithful duplication of the whole ...

Comparison of genomes of closely related species or different isolates within a species show variations at the DNA sequence level or in their structural organization in a chromosome (BARRACLOUGH et al. 2003). The generation ...

Regulation of gene expression is the fundamental aspect of biological phenomena such as responses to environmental conditions, development of multicellular organisms, cellular differentiation, morphology and disease. Gene ...

This thesis analyses the expression, function and regulation of a novel gene, asrij. The early expression of Asrij allows its use as an embryonic stem- cell marker that is down-regulated in nonvascular tissues. Asrij ...