Faculty publications (MBGU): Recent submissions

Now showing items 41-60 of 189

Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials

Hoque, Jiaul; Adhikary, Utsarga; Yadav, Vikas; Samaddar, Sandip; Konai, Mohini Mohan; Prakash, Relekar Gnaneshwar; Pararnanandham, Krishnamoorthy; Shome, Bibek R.; Sanyal, Kaustuv; Haldar, Jayanta (American Chemical Society, 2016)

The continuous rise of antimicrobial resistance and the dearth of new antibiotics in the clinical pipeline raise an urgent call for the development of potent antimicrobial agents. Cationic chitosan derivatives, ...
Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase

Roy, Sourav; Karmakar, Tarak; Nagappa, Lakshmeesha K.; Rao, Vasudeva S. Prahlada; Balasubramanian, Sundaram; Balaram, Hemalatha (Wiley-Blackwell, 2016)

Hypoxanthine-guanine-xanthine phosphoribosyltransference (HGXPRT), a key enzyme in the purine salvage pathway of the malarial parasite, Plasmodium falciparum (Pf), catalyses the conversion of hypoxanthine, guanine, and ...
Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells

Akhade, Vijay Suresh; Dighe, Shrinivas Nivrutti; Kataruka, Shubhangini; Rao, M. R. S. (Oxford University Press, 2016)

Long non coding RNAs (lncRNAs) have emerged as important regulators of various biological processes. LncRNAs also behave as response elements or targets of signaling pathway(s) mediating cellular function. Wnt signaling ...
Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes

Dhanasekaran, Karthigeyan; Kumari, Sujata; Boopathi, Ramachandran; Shima, Hiroki; Swaminathan, Amrutha; Bachu, Mahesh; Ranga, Udaykumar; Igarashi, Kazuhiko; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

Positive coactivator 4 (PC4), a human transcriptional coactivator, is involved in diverse processes like chromatin organization and transcription regulation. It is hyperphosphorylated during mitosis, with unknown significance. ...
A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition

Karthigeyan, Dhanasekaran; Surabhi, Sudhevan; Mizar, Pushpak; Soumik, Siddhanta; Banerjee, Amrita; Sinha, Sarmistha Halder; Dasgupta, Dipak; Narayana, Chandrabhas; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

Aurora kinases are the most commonly targeted mitotic kinases in the intervention of cancer progression. Here, we report a resorcinol derivative, 5-methyl-4(2-thiazolylazo) resorcinol (PTK66), a dual inhibitor of Aurora A ...
Roles for Transcription Factors Sp1, NF-kappa B, IRF3, and IRF7 in Expression of the Human IFNL4 Gene

Chinnaswamy, Sreedhar; Bhushan, Anand; Behera, Amit K.; Ghosh, Sumona; Rampurkar, Vijay; Chandra, Vikas; Pandit, Bhaswati; Kundu, Tapas Kumar (Mary Ann Liebert, Inc, 2016)

The expression of a biologically active human IFN4 depends on the presence of a frameshift deletion polymorphism within the first exon of the interferon lambda 4 (IFNL4) gene. In this report, we use the lung carcinoma-derived ...
Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics

Kaypee, Stephanie; Sudarshan, Deepthi; Shanmugam, Muthu K.; Mukherjee, Debanjan; Sethi, Gautam; Kundu, Tapas Kumar (Pergamon-Elsevier Science Ltd, 2016)

The 'language' of covalent histone modifications translates environmental and cellular cues into gene expression. This vast array of post-translational modifications on histones are more than just covalent moieties added ...
Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction

Swaminathan, Amrutha; Delage, Helene; Chatterjee, Snehajyoti; Belgarbi-Dutron, Laurence; Cassel, Raphaelle; Martinez, Nicole; Cosquer, Brigitte; Kumari, Sujata; Mongelard, Fabien; Lannes, Beatrice; Cassel, Jean-Christophe; Boutillier, Anne-Laurence; Bouvet, Philippe; Kundu, Tapas Kumar (American Society Biochemistry Molecular Biology Inc, 2016)

Although the elaborate combination of histone and non-histone protein complexes defines chromatin organization and hence regulates numerous nuclear processes, the role of chromatin organizing proteins remains unexplored ...
14-3-3 gamma Prevents Centrosome Amplification and Neoplastic Progression

Mukhopadhyay, Amitabha; Sehgal, Lalit; Bose, Arunabha; Gulvady, Anushree; Senapati, Parijat; Thorat, Rahul; Basu, Srikanta; Bhatt, Khyati; Hosing, Amol S.; Balyan, Renu; Borde, Lalit; Kundu, Tapas Kumar; Dalal, Sorab N. (Nature Publishing Group, 2016)

More than 80% of malignant tumors show centrosome amplification and clustering. Centrosome amplification results from aberrations in the centrosome duplication cycle, which is strictly coordinated with DNA-replication-cycle. ...
P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma

Bharathy, Narendra; Suriyamurthy, Sudha; Rao, Vinay Kumar; Ow, Jin Rong; Lim, Huey Jin; Chakraborty, Payal; Vasudevan, Madavan; Dhamne, Chetan Anil; Chang, Kenneth Tou En; Min, Victor Lee Kwan; Kundu, Tapas Kumar; Taneja, Reshma (Wiley-Blackwell, 2016)

Alveolar rhabdomyosarcoma (ARMS) is an aggressive paediatric cancer of skeletal muscle with poor prognosis. A PAX3-FOXO1 fusion protein acts as a driver of malignancy in ARMS by disrupting tightly coupled but mutually ...
FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC

Richard, John Lalith Charles; Shukla, Manu Shubhdarshan; Menoni, Herve; Ouararhni, Khalid; Lone, Imtiaz Nisar; Roulland, Yohan; Papin, Christophe; Ben Simon, Elsa; Kundu, Tapas Kumar; Hamiche, Ali; Angelov, Dimitar; Dimitrov, Stefan (Public Library of Science, 2016)

FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair. Here, we present evidence that FACT could be directly involved ...
Autoregulation of topoisomerase I expression by supercoiling sensitive transcription

Ahmed, Wareed; Menon, Shruti; Karthik, Pullela V. D. N. B.; Nagaraja, Valakunja (Oxford University Press, 2016)

The opposing catalytic activities of topoisomerase I (TopoI/relaxase) and DNA gyrase (supercoiling enzyme) ensure homeostatic maintenance of bacterial chromosome supercoiling. Earlier studies in Es-cherichia coli suggested ...
ZCF32, a fungus specific Zn(II)2 Cys6 transcription factor, is a repressor of the biofilm development in the human pathogen Candida albicans

Kakade, Pallavi; Sadhale, Parag; Sanyal, Kaustuv; Nagaraja, Valakunja (Nature Publishing Group, 2016)

As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ...
Toll-Like Receptor 9 Activation Rescues Impaired Antibody Response in Needle-free Intradermal DNA Vaccination

Arunachalam, Prabhu S.; Mishra, Ria; Badarinath, Krithika; Selvam, Deepak; Payeli, Sravan K.; Stout, Richard R.; Ranga, Udaykumar (Nature Publishing Group, 2016)

The delivery of plasmid DNA to the skin can target distinct subsets of dermal dendritic cells to confer a superior immune response. The needle-free immunization technology offers a reliable, safe and efficient means to ...
The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat

Aralaguppe, Shambhu Prasad G.; Sharma, Shilpee; Menon, Malini; Prasad, Vinayaka R.; Saravanan, Shanmugam; Murugavel, Kailapuri G.; Solomon, Suniti; Ranga, Udaykumar (Mary Ann Liebert, Inc, 2016)

Using several HIV-1 tat exon 1 amino acid sequences available from public databases and additional sequences derived from a southern Indian clinical cohort, we compared the profile of the signature amino acid residues (SAR) ...
Functional Incompatibility between the Generic NF-kappa B Motif and a Subtype-Specific Sp1III Element Drives the Formation of the HIV-1 Subtype C Viral Promoter

Verma, Anjali; Rajagopalan, Pavithra; Lotke, Rishikesh; Varghese, Rebu; Selvam, Deepak; Kundu, Tapas Kumar; Ranga, Udaykumar (American Society Microbiology, 2016)

Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-kappa B binding site found at ...
Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii

Martins-Duarte, Erica S.; Carias, Maira; Vommaro, Rossiane; Surolia, Namita; de Souza, Wanderley (Company Of Biologists Ltd, 2016)

The apicomplexan protozoan Toxoplasma gondii, the causative agent of toxoplasmosis, harbors an apicoplast, a plastid-like organelle with essential metabolic functions. Although the FASII fatty acid biosynthesis pathway ...
Generation of transgenic human embryonic stem cell line BJNhem20-OCIAD1-OV

Shetty, Deeti K.; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Ovarian Carcinoma Immuno-reactive Antigen domain containing protein 1 (OCIAD1) was overexpressed in BJNhem20 human embryonic stem cell line (hESC) using plasmid transfection, followed by stable cell line generation. The ...
Generation of a constitutively expressing Tetracycline repressor (TetR) human embryonic stem cell line BJNhem20-TetR

Shetty, Ronak; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Human embryonic stem cell line BJNhem20-TetR was generated using non-viral method. The construct pCAG-TetRnls was transfected using microporation procedure. BJNhem20-TetR can subsequently be transfected with any vector ...
Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-39

Shetty, Deeti K.; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Ovarian carcinoma immuno-reactive antigen domain containing 1 (OCIAD1) single copy was knocked out generating an OCIAD1 heterozygous knockout human embryonic stem line named BJNhem20-OCIAD1-CRISPR-39. The line was generated ...

Now showing items 41-60 of 189

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