• A probe for ratiometric near-infrared fluorescence and colorimetric hydrogen sulfide detection and imaging in live cells 

  Maity, Debabrata; Raj, Anand; Samanta, Pralok K.; Karthigeyan, D.; Kundu, Tapas Kumar; Pati, Swapan Kumar; Govindaraju, T. (Royal Society of Chemistry, 2014)

  A ratiometric, near-infrared (NIR), fluorescence and colorimetric probe DNPOCy for hydrogen sulfide (H2S) has been developed. The chemical basis for the operation of the probe is thiolysis of a dinitrophenyl ether, which ...
• Oligo(p-phenyleneethynylene)-Derived Porous Luminescent Nanoscale Coordination Polymer of Gd-III: Bimodal Imaging and Nitroaromatic Sensing 

  Suresh, Venkata M.; Chatterjee, Snehajyoti; Modak, Rahul; Tiwari, Vivek; Patel, Anant B.; Kundu, Tapas Kumar; Maji, Tapas Kumar (American Chemical Society, 2014)

  Self-assembled highly luminescent nanoscale coordination polymer of {[Gd(OPE)(NO3)(H2O)2]center dot H2O} (NCP-1), (oligo-(p-phenyleneethynylene)dicarboxylate) was synthesized by coordination-driven self-assembly of ...
• Histone H3K9 acetylation level modulates gene expression and may affect parasite growth in human malaria parasite Plasmodium falciparum 

  Srivastava, Sandeep; Bhowmick, Krishanu; Chatterjee, Snehajyoti; Basha, Jeelan; Kundu, Tapas Kumar; Dhar, Suman K. (Wiley-Blackwell, 2014)

  Three-dimensional positioning of the nuclear genome plays an important role in the epigenetic regulation of genes. Although nucleographic domain compartmentalization in the regulation of epigenetic state and gene expression ...
• Modulation of Neurogenesis by Targeting Epigenetic Enzymes Using Small Molecules: An Overview 

  Swaminathan, Amrutha; Kumar, Manoj; Sinha, Sarmistha Haider; Schneider-Anthony, Anne; Boutillier, Anne-Laurence; Kundu, Tapas Kumar (American Chemical Society, 2014)

  Neurogenesis consists of a plethora of complex cellular processes including neural stem cell (NSC) proliferation, migration, maturation or differentiation to neurons, and finally integration into the pre-existing neural ...
• High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: Role in diabetic retinopathy 

  Kim, Dong-il; Park, Min-jung; Lim, Seul-ki; Choi, Joo-hee; Kim, Jong-choon; Han, Ho-jae; Kundu, Tapas Kumar; Park, Jae-il; Yoon, Kyung-chul; Park, Sang-woo; Park, Jong-sung; Heo, Young-ran; Park, Soo-hyun (Elsevier Science Inc, 2014)

  Hyperglycemia-induced apoptosis of retinal pigment epithelial (RPE) cells is considered to be involved in the progression of diabetic retinopathy. Histone arginine methylation catalyzed by protein arginine methyltransferases ...
• Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo 

  Sethi, Gautam; Chatterjee, Snehajyoti; Rajendran, Peramaiyan; Li, Feng; Shanmugam, Muthu K.; Wong, Kwong Fai; Kumar, Alan Prem; Senapati, Parijat; Behera, Amit K.; Hui, Kam Man; Basha, Jeelan; Natesh, Nagashayana; Luk, John M.; Kundu, Tapas Kumar (Biomed Central Ltd, 2014)

  Background: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including ...
• Gene regulatory networks and epigenetic modifications in cell differentiation 

  Roy, Siddhartha; Kundu, Tapas Kumar (Wiley-Blackwell, 2014)

  It is becoming increasingly clear that the functionalities of an organism are mostly derived from regulation of its gene repertoire. Specialized cell types are created from pluripotent stem cells by regulating expression ...
• Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity 

  Yadav, Vinod Kumar; Thakur, Ram Krishna; Eckloff, Bruce; Baral, Aradhita; Singh, Ankita; Halder, Rashi; Kumar, Akinchan; Alam, Mohammad Parwez; Kundu, Tapas Kumar; Pandita, Raj; Pandita, Tej K.; Wieben, Eric D.; Chowdhury, Shantanu (Oxford University Press, 2014)

  Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and ...
• Epigenetic response in mice mastitis: Role of histone H3 acetylation and microRNA(s) in the regulation of host inflammatory gene expression during Staphylococcus aureus infection 

  Modak, Rahul; Das Mitra, Susweta; Vasudevan, Madavan; Krishnamoorthy, Paramanandhan; Kumar, Manoj; Bhat, Akshay V.; Bhuvana, Mani; Ghosh, Sankar K.; Shome, Bibek R.; Kundu, Tapas Kumar (Biomed Central Ltd, 2014)

  Background: There is renewed interest towards understanding the host-pathogen interaction in the light of epigenetic modifications. Although epithelial tissue is the major site for host-pathogen interactions, there is ...
• Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression 

  Shandilya, Jayasha; Senapati, Parijat; Dhanasekaran, Karthigeyan; Bangalore, Suma S.; Kumar, Manoj; Kishore, A. Hari; Bhat, Akshay; Kodaganur, Gopinath S.; Kundu, Tapas Kumar (Elsevier Science Bv, 2014)

  The functional association of NPM1 with Aurora ldnases is well documented. Surprisingly, although NPM1 is a well characterized phosphoprotein, it is unknown whether it is a substrate of Aurora kinases. We have found that ...
• Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1 

  Shandilya, Jayasha; Senapati, Parijat; Hans, Fabienne; Menoni, Herve; Bouvet, Philippe; Dimitrov, Stefan; Angelov, Dimitar; Kundu, Tapas Kumar (Oxford University Press, 2014)

  Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through ...
• Drug Discovery Research in India: Current State and Future Prospects 

  Balganesh, Tanjore; Kundu, Tapas Kumar; Chakraborty, Tushar Kanti; Roy, Siddhartha (American Chemical Society, 2014)

  Indian civilization developed a strong system of traditional medicine and was one of the first nations to develop a synthetic drug. In the postindependence era, Indian pharmaceutical industry developed a strong base for ...
• A Thiazole Coumarin (TC) Turn-On Fluorescence Probe for AT-Base Pair Detection and Multipurpose Applications in Different Biological Systems 

  Narayanaswamy, Nagarjun; Kumar, Manoj; Das, Sadhan; Sharma, Rahul; Samanta, Pralok K.; Pati, Swapan Kumar; Dhar, Suman K.; Kundu, Tapas Kumar; Govindaraju, T. (Nature Publishing Group, 2014)

  Sequence-specific recognition of DNA by small turn-on fluorescence probes is a promising tool for bioimaging, bioanalytical and biomedical applications. Here, the authors report a novel cell-permeable and red fluorescent ...
• Naphthoquinone-mediated Inhibition of Lysine Acetyltransferase KAT3B/p300, Basis for Non-toxic Inhibitor Synthesis 

  Vasudevarao, Mohankrishna Dalvoy; Mizar, Pushpak; Kumari, Sujata; Mandal, Somnath; Siddhanta, Soumik; Swamy, Mahadeva M. M.; Kaypee, Stephanie; Kodihalli, Ravindra C.; Banerjee, Amrita; Naryana, Chandrabhas; Dasgupta, Dipak; Kundu, Tapas Kumar (American Society Biochemistry Molecular Biology Inc, 2014)

  Background: 1,4-Naphthoquinone analogs, such as plumbagin, are toxic compounds due to their redox cycling and thiol-reactive properties. Results: The p300 inhibitor PTK1, a plumbagin derivative with greatly reduced toxicity, ...
• SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool 

  Karthigeyan, Dhanasekaran; Siddhanta, Soumik; Kishore, Annavarapu Hari; Perumal, Sathya S. R. R.; Agren, Hans; Sudevan, Surabhi; Bhat, Akshay V.; Balasubramanyam, Karanam; Subbegowda, Rangappa Kanchugarakoppal; Kundu, Tapas Kumar; Narayana, Chandrabhas (National Academy of Sciences, 2014)

  We demonstrate the use of surface-enhanced Raman spectroscopy (SERS) as an excellent tool for identifying the binding site of small molecules on a therapeutically important protein. As an example, we show the specific ...
• Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes 

  Dhanasekaran, Karthigeyan; Kumari, Sujata; Boopathi, Ramachandran; Shima, Hiroki; Swaminathan, Amrutha; Bachu, Mahesh; Ranga, Udaykumar; Igarashi, Kazuhiko; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

  Positive coactivator 4 (PC4), a human transcriptional coactivator, is involved in diverse processes like chromatin organization and transcription regulation. It is hyperphosphorylated during mitosis, with unknown significance. ...
• A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition 

  Karthigeyan, Dhanasekaran; Surabhi, Sudhevan; Mizar, Pushpak; Soumik, Siddhanta; Banerjee, Amrita; Sinha, Sarmistha Halder; Dasgupta, Dipak; Narayana, Chandrabhas; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

  Aurora kinases are the most commonly targeted mitotic kinases in the intervention of cancer progression. Here, we report a resorcinol derivative, 5-methyl-4(2-thiazolylazo) resorcinol (PTK66), a dual inhibitor of Aurora A ...
• Roles for Transcription Factors Sp1, NF-kappa B, IRF3, and IRF7 in Expression of the Human IFNL4 Gene 

  Chinnaswamy, Sreedhar; Bhushan, Anand; Behera, Amit K.; Ghosh, Sumona; Rampurkar, Vijay; Chandra, Vikas; Pandit, Bhaswati; Kundu, Tapas Kumar (Mary Ann Liebert, Inc, 2016)

  The expression of a biologically active human IFN4 depends on the presence of a frameshift deletion polymorphism within the first exon of the interferon lambda 4 (IFNL4) gene. In this report, we use the lung carcinoma-derived ...
• Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics 

  Kaypee, Stephanie; Sudarshan, Deepthi; Shanmugam, Muthu K.; Mukherjee, Debanjan; Sethi, Gautam; Kundu, Tapas Kumar (Pergamon-Elsevier Science Ltd, 2016)

  The 'language' of covalent histone modifications translates environmental and cellular cues into gene expression. This vast array of post-translational modifications on histones are more than just covalent moieties added ...
• Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction 

  Swaminathan, Amrutha; Delage, Helene; Chatterjee, Snehajyoti; Belgarbi-Dutron, Laurence; Cassel, Raphaelle; Martinez, Nicole; Cosquer, Brigitte; Kumari, Sujata; Mongelard, Fabien; Lannes, Beatrice; Cassel, Jean-Christophe; Boutillier, Anne-Laurence; Bouvet, Philippe; Kundu, Tapas Kumar (American Society Biochemistry Molecular Biology Inc, 2016)

  Although the elaborate combination of histone and non-histone protein complexes defines chromatin organization and hence regulates numerous nuclear processes, the role of chromatin organizing proteins remains unexplored ...

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