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Now showing items 1-20 of 62

14-3-3 gamma Prevents Centrosome Amplification and Neoplastic Progression

Mukhopadhyay, Amitabha; Sehgal, Lalit; Bose, Arunabha; Gulvady, Anushree; Senapati, Parijat; Thorat, Rahul; Basu, Srikanta; Bhatt, Khyati; Hosing, Amol S.; Balyan, Renu; Borde, Lalit; Kundu, Tapas Kumar; Dalal, Sorab N. (Nature Publishing Group, 2016)

More than 80% of malignant tumors show centrosome amplification and clustering. Centrosome amplification results from aberrations in the centrosome duplication cycle, which is strictly coordinated with DNA-replication-cycle. ...
Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics

Kaypee, Stephanie; Sudarshan, Deepthi; Shanmugam, Muthu K.; Mukherjee, Debanjan; Sethi, Gautam; Kundu, Tapas Kumar (Pergamon-Elsevier Science Ltd, 2016)

The 'language' of covalent histone modifications translates environmental and cellular cues into gene expression. This vast array of post-translational modifications on histones are more than just covalent moieties added ...
Acetylated NPM1 Localizes in the Nucleoplasm and Regulates Transcriptional Activation of Genes Implicated in Oral Cancer Manifestation

Shandilya, Jayasha; Swaminathan, Venkatesh; Gadad, Shrikanth S; Choudhari, Ramesh; Kodaganur, Gopinath S; Kundu, Tapas K (American Society for Microbiology, 2009-09-15)

Nucleophosmin (NPM1) is a multifunctional protein involved in the regulation of centrosome duplication, ribosome biogenesis, genomic stability, histone chaperone function, and transcription. Overexpression of NPM1 is ...
Acetylation of Transition Protein 2 (TP2) by KAT3B (p300) Alters Its DNA Condensation Property and Interaction with Putative Histone Chaperone NPM3

Pradeepa, Madapura M; Nikhil, Gupta; Kishore, Annavarapu Hari; Bharath, Giriyapura N; Kundu, Tapas K; Rao, M R S (American Society for Biochemistry and Molecular Biology Inc, 2009-10-23)

The hallmark of mammalian spermiogenesis is the dramatic chromatin remodeling process wherein the nucleosomal histones are replaced by the transition proteins TP1, TP2, and TP4. Subsequently these transition proteins are ...
Activation Of P300 Histone Acetyltransferase By Small Molecules Altering Enzyme Structure: Period Probed By Surface Enhanced Raman Spectroscopy

Mantelingu, K; Kishore, A Hari; Balasubramanyam, K; Kumar, G V Pavan; Altaf, M; Swamy, S Nanjunda; Selvi, Ruthrotha; Das, Chandrima; Narayana, Chandrabhas; Rangappa, K S; Kundu, Tapas K (American Chemical Society, 2007-05-03)

Reversible acetylation of nucleosomal histones and nonhistone proteins play pivotal roles in the regulation of all the DNA templated phenomenon. Dysfunction of the enzymes involved in the acetylation/deacetylation leads ...
Activation of p53 function by human transcriptional coactivator PC4: Role of protein-protein interaction, DNA bending, and Posttranslational modifications

Batta, Kiran; Kundu, Tapas K (American Society for Microbiology, 2007-11)

Tumor suppressor p53 controls cell cycle checkpoints and apoptosis via the transactivation of several genes that are involved in these processes. The functions of p53 are regulated by a wide variety of proteins, which ...
Autoacetylation Induced Specific Structural Changes In Histone Acetyltransferase Domain Of P300: Probed By Surface Enhanced Raman Spectroscopy

Arif, Mohammed; Kumar, G V Pavan; Narayana, Chandrabhas; Kundu, Tapas K (American Chemical Society, 2007-10-18)

Reversible acetylation of histone and non-histone proteins plays an important role in the regulation of gene expression and cellular homeostasis. A balance between acetylation and deacetylation of these proteins are ...
Biology of Aurora A Kinase: Implications in Cancer Manifestation and Therapy

Karthigeyan, Dhanasekaran; Benaka Prasad, Sallekoppal B; Shandilya, Jayasha; Agrawal, Shipra; Kundu, Tapas K (Wiley Blackwell, 2010-03-01)

The Aurora A kinase belongs to serine/threonine group of kinases, well known for its role in cell cycle, especially in the regulation of mitosis. Numerous substrates of Aurora A kinase have been identified, which are ...
CARM1 regulates astroglial lineage through transcriptional regulation of Nanog and posttranscriptional regulation by miR92a

Selvi, B. Ruthrotha; Swaminathan, Amrutha; Maheshwari, Uma; Nagabhushana, Ananthamurthy; Mishra, Rakesh K.; Kundu, Tapas Kumar (American Society for Cell Biology, 2015)

Coactivator-associated arginine methyltransferase (CARM1/PRMT4)-mediated transcriptional coactivation and arginine methylation is known to regulate various tissue-specific differentiation events. Although CARM1 is expressed ...
Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadashivam, Subhashini; Gupta, Sanjeev; Radha, Vegesna; Batta, Kiran; Kundu, Tapas K; Swarup, Ghanshyam (Nature Publishing Group, 2005-01-20)

The tumor suppressor protein p53 regulates transcription of many genes that mediate cell cycle arrest, apoptosis, DNA repair and other cellular responses. Here we show that Ipaf, a human CED-4 homologue and an activator ...
Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1

Shandilya, Jayasha; Senapati, Parijat; Hans, Fabienne; Menoni, Herve; Bouvet, Philippe; Dimitrov, Stefan; Angelov, Dimitar; Kundu, Tapas Kumar (Oxford University Press, 2014)

Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through ...
A Constrained Helical Peptide Against S100A4 Inhibits Cell Motility in Tumor Cells

Naiya, Gitashri; Kaypee, Stephanie; Kundu, Tapas Kumar; Roy, Siddhartha (Wiley-Blackwell, 2015)

S100A4, a member of a calcium-regulated protein family, is involved in various cellular signaling pathways. From many studies over the last decade or so, it has become clear that it is involved in tumor metastasis, probably ...
Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Balasubramanyam, Karanam; Varier, Radhika A; Altaf, Mohammed; Swaminathan, Venkatesh; Siddappa, Nagadenahalli B; Ranga, Udaykumar; Kundu, Tapas K (American Society for Biochemistry and Molecular Biology Inc, 2004-12-03)

Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral DNA that integrates into the human genome ( e. g. ...
DNA Condensation by the Rat Spermatidal Protein TP2 Shows GC-Rich Sequence Preference and Is Zinc Dependent

Kundu, Tapas K; Rao, M R S (American Chemical Society, 1995-04-18)

Transition protein-2 (TP2), isolated from rat testes, was recently shown to be a zinc metalloprotein. We have now carried out a detailed analysis of the DNA condensing properties of TP2 with various polynucleotides using ...
Drug Discovery Research in India: Current State and Future Prospects

Balganesh, Tanjore; Kundu, Tapas Kumar; Chakraborty, Tushar Kanti; Roy, Siddhartha (American Chemical Society, 2014)

Indian civilization developed a strong system of traditional medicine and was one of the first nations to develop a synthetic drug. In the postindependence era, Indian pharmaceutical industry developed a strong base for ...
A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition

Karthigeyan, Dhanasekaran; Surabhi, Sudhevan; Mizar, Pushpak; Soumik, Siddhanta; Banerjee, Amrita; Sinha, Sarmistha Halder; Dasgupta, Dipak; Narayana, Chandrabhas; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

Aurora kinases are the most commonly targeted mitotic kinases in the intervention of cancer progression. Here, we report a resorcinol derivative, 5-methyl-4(2-thiazolylazo) resorcinol (PTK66), a dual inhibitor of Aurora A ...
Enhanced DNA dynamics due to cationic reagents, topological states of dsDNA and high mobility group box 1 as probed by PicoGreen

Noothi, Sunil K; Kombrabail, Mamata; Kundu, Tapas K; Krishnamoorthy, G; Rao, Basuthkar J (Wiley-BLackwell Publishing, 2009-01)

We report a study of dynamics with a dsDNA-specific dye called PicoGreen bound to plasmid DNA (3.4 kb), and show that at low dye/DNA phosphate ratios (1 : 100 and below), PicoGreen dynamics reflect the motional dynamics ...
Epigenetic response in mice mastitis: Role of histone H3 acetylation and microRNA(s) in the regulation of host inflammatory gene expression during Staphylococcus aureus infection

Modak, Rahul; Das Mitra, Susweta; Vasudevan, Madavan; Krishnamoorthy, Paramanandhan; Kumar, Manoj; Bhat, Akshay V.; Bhuvana, Mani; Ghosh, Sankar K.; Shome, Bibek R.; Kundu, Tapas Kumar (Biomed Central Ltd, 2014)

Background: There is renewed interest towards understanding the host-pathogen interaction in the light of epigenetic modifications. Although epithelial tissue is the major site for host-pathogen interactions, there is ...
FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC

Richard, John Lalith Charles; Shukla, Manu Shubhdarshan; Menoni, Herve; Ouararhni, Khalid; Lone, Imtiaz Nisar; Roulland, Yohan; Papin, Christophe; Ben Simon, Elsa; Kundu, Tapas Kumar; Hamiche, Ali; Angelov, Dimitar; Dimitrov, Stefan (Public Library of Science, 2016)

FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair. Here, we present evidence that FACT could be directly involved ...
Functional Incompatibility between the Generic NF-kappa B Motif and a Subtype-Specific Sp1III Element Drives the Formation of the HIV-1 Subtype C Viral Promoter

Verma, Anjali; Rajagopalan, Pavithra; Lotke, Rishikesh; Varghese, Rebu; Selvam, Deepak; Kundu, Tapas Kumar; Ranga, Udaykumar (American Society Microbiology, 2016)

Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-kappa B binding site found at ...

Now showing items 1-20 of 62

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