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Browsing Tapas Kumar Kundu by Author

Browsing Tapas Kumar Kundu by Author "Balasubramanyam, Karanam"

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Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Balasubramanyam, Karanam; Varier, Radhika A; Altaf, Mohammed; Swaminathan, Venkatesh; Siddappa, Nagadenahalli B; Ranga, Udaykumar; Kundu, Tapas K (American Society for Biochemistry and Molecular Biology Inc, 2004-12-03)

Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral DNA that integrates into the human genome ( e. g. ...
Polyisoprenylated Benzophenone, Garcinol, a Natural Histone Acetyltransferase Inhibitor, Represses Chromatin Transcription and Alters Global Gene Expression

Balasubramanyam, Karanam; Altaf, M; Varier, Radhika A; Swaminathan, V; Ravindran, Aarti; Sadhale, Parag P; Kundu, Tapas K (American Society for Biochemistry and Molecular Biology Inc, 2004-08-06)

Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs) are key regulatory steps for gene expression ...
SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool

Karthigeyan, Dhanasekaran; Siddhanta, Soumik; Kishore, Annavarapu Hari; Perumal, Sathya S. R. R.; Agren, Hans; Sudevan, Surabhi; Bhat, Akshay V.; Balasubramanyam, Karanam; Subbegowda, Rangappa Kanchugarakoppal; Kundu, Tapas Kumar; Narayana, Chandrabhas (National Academy of Sciences, 2014)

We demonstrate the use of surface-enhanced Raman spectroscopy (SERS) as an excellent tool for identifying the binding site of small molecules on a therapeutically important protein. As an example, we show the specific ...
Small Molecule Modulators of Histone Acetyltransferase p300*

Balasubramanyam, Karanam; Swaminathan, V; Ranganathan, Anupama; Kundu, Tapas K (The American Society for Biochemistry and Molecular Biology Inc, 2003-05-23)

Histone acetyltransferases (HATs) are a group of enzymes that play a significant role in the regulation of gene expression. These enzymes covalently modify the N-terminal lysine residues of histones by the addition of ...
The Transcriptional Coactivator P300 Plays A Critical Role In The Hypertrophic And Protective Pathways Induced By Phenylephrine On Cardiac Cells But Is Specific To The Hypertrophic Effect Of Urocortin

Davidson, Sean M; Townsend, Paul A; Carroll, Chris; Yurek-George, Alexander; Balasubramanyam, Karanam; Kundu, Tapas K; Stephanou, Anastasis; Packham, Graham; Ganesan, A; Latchman, David S (Wiley-Blackwell, 2005-01)

Anacardic acid is an alkylsalicylic acid obtained from cashewnut-shell liquid, and is a potent inhibitor of p300 histone acetyltransferase (HAT) activity. We have used anacardic acid to prevent the induction of hypertrophy ...

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Browsing Tapas Kumar Kundu by Author "Balasubramanyam, Karanam"

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