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Tapas Kumar Kundu
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Browsing Research Papers (Tapas K. Kundu) by Issue Date

Browsing Research Papers (Tapas K. Kundu) by Issue Date

Now showing items 1-20 of 62

DNA Condensation by the Rat Spermatidal Protein TP2 Shows GC-Rich Sequence Preference and Is Zinc Dependent

Kundu, Tapas K; Rao, M R S (American Chemical Society, 1995-04-18)

Transition protein-2 (TP2), isolated from rat testes, was recently shown to be a zinc metalloprotein. We have now carried out a detailed analysis of the DNA condensing properties of TP2 with various polynucleotides using ...
Small Molecule Modulators of Histone Acetyltransferase p300*

Balasubramanyam, Karanam; Swaminathan, V; Ranganathan, Anupama; Kundu, Tapas K (The American Society for Biochemistry and Molecular Biology Inc, 2003-05-23)

Histone acetyltransferases (HATs) are a group of enzymes that play a significant role in the regulation of gene expression. These enzymes covalently modify the N-terminal lysine residues of histones by the addition of ...
General Transcriptional Coactivator PC4 Activates p53 Function

Banerjee, Sourav; Kumar, B R Prashanth; Kundu, Tapas K (American Society for Microbiology, 2004-03)

The function of p53 is modulated by several transcriptional coactivators that regulate its tumor suppressor activity. Here we report that human transcriptional coactivator PC4 enhances the DNA binding of p53 to its cognate ...
Polyisoprenylated Benzophenone, Garcinol, a Natural Histone Acetyltransferase Inhibitor, Represses Chromatin Transcription and Alters Global Gene Expression

Balasubramanyam, Karanam; Altaf, M; Varier, Radhika A; Swaminathan, V; Ravindran, Aarti; Sadhale, Parag P; Kundu, Tapas K (American Society for Biochemistry and Molecular Biology Inc, 2004-08-06)

Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs) are key regulatory steps for gene expression ...
Transcription Through Chromatin – Link to Diseases and Therapeutics

A, Hari Kishore; Iyengar, Sushma S; Kundu, Tapas K (Springer, 2004-11)

The expression of chromosomal genes is regulated by posttranslational modification of both histone and nonhistone chromatin proteins and ATP-dependent remodeling of chromatin. Dysfunction of the modification and remodeling ...
Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Balasubramanyam, Karanam; Varier, Radhika A; Altaf, Mohammed; Swaminathan, Venkatesh; Siddappa, Nagadenahalli B; Ranga, Udaykumar; Kundu, Tapas K (American Society for Biochemistry and Molecular Biology Inc, 2004-12-03)

Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral DNA that integrates into the human genome ( e. g. ...
The Transcriptional Coactivator P300 Plays A Critical Role In The Hypertrophic And Protective Pathways Induced By Phenylephrine On Cardiac Cells But Is Specific To The Hypertrophic Effect Of Urocortin

Davidson, Sean M; Townsend, Paul A; Carroll, Chris; Yurek-George, Alexander; Balasubramanyam, Karanam; Kundu, Tapas K; Stephanou, Anastasis; Packham, Graham; Ganesan, A; Latchman, David S (Wiley-Blackwell, 2005-01)

Anacardic acid is an alkylsalicylic acid obtained from cashewnut-shell liquid, and is a potent inhibitor of p300 histone acetyltransferase (HAT) activity. We have used anacardic acid to prevent the induction of hypertrophy ...
Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadashivam, Subhashini; Gupta, Sanjeev; Radha, Vegesna; Batta, Kiran; Kundu, Tapas K; Swarup, Ghanshyam (Nature Publishing Group, 2005-01-20)

The tumor suppressor protein p53 regulates transcription of many genes that mediate cell cycle arrest, apoptosis, DNA repair and other cellular responses. Here we show that Ipaf, a human CED-4 homologue and an activator ...
Transcriptional Regulation by the Acetylation of Nonhistone Proteins in Humans – A New Target for Therapeutics

Das, Chandrima; Kundu, Tapas K (Taylor & Francis Inc, 2005-03)

Gene expression from the dynamic chromatin template is regulated by certain key cellular players that cause post-translational modi. cations of both histones and nonhistone proteins. The acetyltransferases and deacetylases ...
Human Histone Chaperone Nucleophosmin Enhances Acetylation-Dependent Chromatin Transcription

Swaminathan, V; Kishore, A Hari; Febitha, K K; Kundu, Tapas K (American Society for Microbiology, 2005-09)

Histone chaperones are a group of proteins that aid in the dynamic chromatin organization during different cellular processes. Here, we report that the human histone chaperone nucleophosmin interacts with the core histones ...
Tumor Suppressor SMAR1 Mediates Cyclin D1 Repression by Recruitment of the SIN3/Histone Deacetylase 1 Complex

Rampalli, Shravanti; Pavithra, L; Bhatt, Altaf; Kundu, Tapas K; Chattopadhyay, Samit (American Society for Microbiology, 2005-10)

Matrix attachment region binding proteins have been shown to play an important role in gene regulation by altering chromatin in a stage- and tissue-specific manner. Our previous studies report that SMAR1, a matrix-associated ...
Surface-Enhanced Raman Scattering Studies of Human Transcriptional Coactivator p300

Kumar, G V Pavan; Reddy, B A Ashok; Arif, Mohammed; Kundu, Tapas K; Narayana, Chandrabhas (American Chemical Society, 2006-08-24)

We report for the first time the surface-enhanced Raman scattering (SERS) studies on p300, a large multidomain transcriptional coactivator protein. Vibration spectral analysis has been performed in an attempt to understand ...
Transcriptional Coactivator PC4, a Chromatin-Associated Protein, Induces Chromatin Condensation

Das, Chandrima; Hizume, Kohji; Batta, Kiran; Kumar, B R Prashanth; Gadad, Shrikanth S; Ganguly, Semanti; Lorain, Stephanie; Verreault, Alain; Sadhale, Parag P; Takeyasu, Kunio; Kundu, Tapas K (American Society for Microbiology, 2006-11)

Human transcriptional coactivator PC4 is a highly abundant multifunctional protein which plays diverse important roles in cellular processes, including transcription, replication, and repair. It is also a unique activator ...
Hot Spots in Ag Core-Au Shell Nanoparticles Potent for Surface-Enhanced Raman Scattering Studies of Biomolecules

Kumar, G V Pavan; Shruthi, S; Vibha, B; Reddy, B A Ashok; Kundu, Tapas K; Narayana, Chandrabhas (American Chemical Society, 2007-03-22)

The vicinity of metallic nanostructures that provides intense optical fields is termed as "hot spot". Any molecule in close proximity to these hot spots will give rise to an increased surface-enhanced Raman spectroscopic ...
Activation Of P300 Histone Acetyltransferase By Small Molecules Altering Enzyme Structure: Period Probed By Surface Enhanced Raman Spectroscopy

Mantelingu, K; Kishore, A Hari; Balasubramanyam, K; Kumar, G V Pavan; Altaf, M; Swamy, S Nanjunda; Selvi, Ruthrotha; Das, Chandrima; Narayana, Chandrabhas; Rangappa, K S; Kundu, Tapas K (American Chemical Society, 2007-05-03)

Reversible acetylation of nucleosomal histones and nonhistone proteins play pivotal roles in the regulation of all the DNA templated phenomenon. Dysfunction of the enzymes involved in the acetylation/deacetylation leads ...
Specific Inhibition of p300-HAT Alters Global Gene Expression and Represses HIV Replication

Mantelingu, K; Reddy, B A Ashok; Swaminathan, V; Hari Kishore, A; Siddappa, Nagadenahalli B; Pavan Kumar, G V; Nagashankar, G; Natesh, Nagashayana; Roy, Siddhartha; Sadhale, Parag P; Ranga, Udaykumar; Narayana, Chandrabhas; Kundu, Tapas K (Cell Press, 2007-06)

Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, ...
p53 regulates its own activator: transcriptional co-activator PC4, a new p53-responsive gene

Kishore, A Hari; Batta, Kiran; Das, Chandrima; Agarwal, Shipra; Kundu, Tapas K (Biochemical Society(PortLand Press Ltd), 2007-09-15)

The tumour suppressor protein p53 regulates the expression of several genes that mediate cell cycle arrest, apoptosis, DNA repair and other cellular responses. Recently, we have shown that human transcriptional co-activator ...
Autoacetylation Induced Specific Structural Changes In Histone Acetyltransferase Domain Of P300: Probed By Surface Enhanced Raman Spectroscopy

Arif, Mohammed; Kumar, G V Pavan; Narayana, Chandrabhas; Kundu, Tapas K (American Chemical Society, 2007-10-18)

Reversible acetylation of histone and non-histone proteins plays an important role in the regulation of gene expression and cellular homeostasis. A balance between acetylation and deacetylation of these proteins are ...
Activation of p53 function by human transcriptional coactivator PC4: Role of protein-protein interaction, DNA bending, and Posttranslational modifications

Batta, Kiran; Kundu, Tapas K (American Society for Microbiology, 2007-11)

Tumor suppressor p53 controls cell cycle checkpoints and apoptosis via the transactivation of several genes that are involved in these processes. The functions of p53 are regulated by a wide variety of proteins, which ...
Specific Small-Molecule Activator of Aurora Kinase A Induces Autophosphorylation in a Cell-Free System

Kishore, A Hari; Vedamurthy, B M; Mantelingu, K; Agrawal, Shipra; Reddy, B A Ashok; Roy, Siddhartha; Rangappa, K S; Kundu, Tapas K (American Chemical Society, 2008-01-24)

Aurora kinases are essential for chromosomal segregation and cell division and thereby important for maintaining the proper genomic integrity. There are three classes of aurora kinases in humans: A, B, and C. Aurora kinase ...

Now showing items 1-20 of 62

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