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Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1

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dc.contributor.author Shandilya, Jayasha
dc.contributor.author Senapati, Parijat
dc.contributor.author Hans, Fabienne
dc.contributor.author Menoni, Herve
dc.contributor.author Bouvet, Philippe
dc.contributor.author Dimitrov, Stefan
dc.contributor.author Angelov, Dimitar
dc.contributor.author Kundu, Tapas Kumar
dc.date.accessioned 2017-02-17T05:09:15Z
dc.date.available 2017-02-17T05:09:15Z
dc.date.issued 2014
dc.identifier.citation Shandilya, J; Senapati, P; Hans, F; Menoni, H; Bouvet, P; Dimitrov, S; Angelov, D; Kundu, TK, Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1. Journal of Biochemistry 2014, 156 (4) 221-227, http://dx.doi.org/10.1093/jb/mvu034 en_US
dc.identifier.citation Journal of Biochemistry en_US
dc.identifier.citation 156 en_US
dc.identifier.citation 4 en_US
dc.identifier.issn 0021-924X
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2328
dc.description Restricted Access en_US
dc.description.abstract Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through an unknown mechanism. Here, we report that reconstituted CENP-A nucleosomes are amenable to ATP-dependent SWI/SNF-mediated remodelling but are less permissive to acetylation and acetylation-dependent in vitro chromatin transcription. Remarkably, the transcriptional repression of the CENP-A chromatinized template could be relieved by the ectopic addition of histone chaperone, nucleophosmin. en_US
dc.description.uri 1756-2651 en_US
dc.description.uri http://dx.doi.org/10.1093/jb/mvu034 en_US
dc.language.iso English en_US
dc.publisher Oxford University Press en_US
dc.rights @Oxford University Press, 2014 en_US
dc.subject Biochemistry & Molecular Biology en_US
dc.subject Acetylation en_US
dc.subject Cenp-A en_US
dc.subject Histone Chaperone en_US
dc.subject Npm1 en_US
dc.subject Transcription en_US
dc.subject In-Vitro en_US
dc.subject Nucleosome Reconstitution en_US
dc.subject Protein-A en_US
dc.subject Expression en_US
dc.subject Purification en_US
dc.subject Complex en_US
dc.subject HJURP en_US
dc.title Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1 en_US
dc.type Article en_US


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