dc.contributor.author |
Shandilya, Jayasha
|
|
dc.contributor.author |
Senapati, Parijat
|
|
dc.contributor.author |
Hans, Fabienne
|
|
dc.contributor.author |
Menoni, Herve
|
|
dc.contributor.author |
Bouvet, Philippe
|
|
dc.contributor.author |
Dimitrov, Stefan
|
|
dc.contributor.author |
Angelov, Dimitar
|
|
dc.contributor.author |
Kundu, Tapas Kumar
|
|
dc.date.accessioned |
2017-02-17T05:09:15Z |
|
dc.date.available |
2017-02-17T05:09:15Z |
|
dc.date.issued |
2014 |
|
dc.identifier.citation |
Shandilya, J; Senapati, P; Hans, F; Menoni, H; Bouvet, P; Dimitrov, S; Angelov, D; Kundu, TK, Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1. Journal of Biochemistry 2014, 156 (4) 221-227, http://dx.doi.org/10.1093/jb/mvu034 |
en_US |
dc.identifier.citation |
Journal of Biochemistry |
en_US |
dc.identifier.citation |
156 |
en_US |
dc.identifier.citation |
4 |
en_US |
dc.identifier.issn |
0021-924X |
|
dc.identifier.uri |
https://libjncir.jncasr.ac.in/xmlui/10572/2328 |
|
dc.description |
Restricted Access |
en_US |
dc.description.abstract |
Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through an unknown mechanism. Here, we report that reconstituted CENP-A nucleosomes are amenable to ATP-dependent SWI/SNF-mediated remodelling but are less permissive to acetylation and acetylation-dependent in vitro chromatin transcription. Remarkably, the transcriptional repression of the CENP-A chromatinized template could be relieved by the ectopic addition of histone chaperone, nucleophosmin. |
en_US |
dc.description.uri |
1756-2651 |
en_US |
dc.description.uri |
http://dx.doi.org/10.1093/jb/mvu034 |
en_US |
dc.language.iso |
English |
en_US |
dc.publisher |
Oxford University Press |
en_US |
dc.rights |
@Oxford University Press, 2014 |
en_US |
dc.subject |
Biochemistry & Molecular Biology |
en_US |
dc.subject |
Acetylation |
en_US |
dc.subject |
Cenp-A |
en_US |
dc.subject |
Histone Chaperone |
en_US |
dc.subject |
Npm1 |
en_US |
dc.subject |
Transcription |
en_US |
dc.subject |
In-Vitro |
en_US |
dc.subject |
Nucleosome Reconstitution |
en_US |
dc.subject |
Protein-A |
en_US |
dc.subject |
Expression |
en_US |
dc.subject |
Purification |
en_US |
dc.subject |
Complex |
en_US |
dc.subject |
HJURP |
en_US |
dc.title |
Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1 |
en_US |
dc.type |
Article |
en_US |