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Modulation of Neurogenesis by Targeting Epigenetic Enzymes Using Small Molecules: An Overview

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dc.contributor.author Swaminathan, Amrutha
dc.contributor.author Kumar, Manoj
dc.contributor.author Sinha, Sarmistha Haider
dc.contributor.author Schneider-Anthony, Anne
dc.contributor.author Boutillier, Anne-Laurence
dc.contributor.author Kundu, Tapas Kumar
dc.date.accessioned 2017-02-17T05:09:16Z
dc.date.available 2017-02-17T05:09:16Z
dc.date.issued 2014
dc.identifier.citation Swaminathan, A; Kumar, M; Sinha, SH; Schneider-Anthony, A; Boutillier, AL; Kundu, TK, Modulation of Neurogenesis by Targeting Epigenetic Enzymes Using Small Molecules: An Overview. ACS Chemical Neuroscience 2014, 5 (12) 1164-1177, http://dx.doi.org/10.1021/cn500117a en_US
dc.identifier.citation ACS Chemical Neuroscience en_US
dc.identifier.citation 5 en_US
dc.identifier.citation 12 en_US
dc.identifier.issn 1948-7193
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2335
dc.description Restricted Access en_US
dc.description.abstract Neurogenesis consists of a plethora of complex cellular processes including neural stem cell (NSC) proliferation, migration, maturation or differentiation to neurons, and finally integration into the pre-existing neural circuits in the brain, which are temporally regulated and coordinated sequentially. Mammalian neurogenesis begins during embryonic development and continues in postnatal brain (adult neurogenesis). It is now evident that adult neurogenesis is driven by extracellular and intracellular signaling pathways, where epigenetic modifications like reversible histone acetylation, methylation, as well as DNA methylation play a vital role. Epigenetic regulation of gene expression during neural development is governed mainly by histone acetyltransferases (HATs), histone methyltransferase (HMTs), DNA methyltransferases (DNMTs), and also the enzymes for reversal, like histone deacetylases (HDACS), and many of these have also been shown to be involved in the regulation of adult neurogenesis. The contribution of these epigenetic marks to neurogenesis is increasingly being recognized, through knockout studies and small molecule modulator based studies. These small molecules are directly involved in regeneration and repair of neurons, and not only have applications from a therapeutic point of view, but also provide a tool to study the process of neurogenesis itself. In the present Review, we will focus on small molecules that act predominantly on epigenetic enzymes to enhance neurogenesis and neuroprotection and discuss the mechanism and recent advancements in their synthesis, targeting, and biology. en_US
dc.description.uri http://dx.doi.org/10.1021/cn500117a en_US
dc.language.iso English en_US
dc.publisher American Chemical Society en_US
dc.rights @American Chemical Society, 2014 en_US
dc.subject Biochemistry & Molecular Biology en_US
dc.subject Medicinal Chemistry en_US
dc.subject Neurosciences en_US
dc.subject Neurogenesis en_US
dc.subject Histone Modifications en_US
dc.subject Acetyltransferase en_US
dc.subject DNA Methylation en_US
dc.subject Memory en_US
dc.subject Neurodegeneration en_US
dc.subject Neurotherapeutics en_US
dc.subject Adult Hippocampal Neurogenesis en_US
dc.subject Central-Nervous-System en_US
dc.subject Binding Protein Hud en_US
dc.subject Neural Stem-Cells en_US
dc.subject Histone Deacetylase Inhibition en_US
dc.subject Rubinstein-Taybi-Syndrome en_US
dc.subject Messenger-RNA Expression en_US
dc.subject Focal Cerebral-Ischemia en_US
dc.subject Bdnf Gene-Transcription en_US
dc.subject Dentate Granule Cells en_US
dc.title Modulation of Neurogenesis by Targeting Epigenetic Enzymes Using Small Molecules: An Overview en_US
dc.type Review en_US


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