DSpace Repository

Septin complex as a novel regulator of autophagosome biogenesis

Show simple item record

dc.contributor.advisor Manjithaya, Ravi
dc.contributor.author Barve, Gaurav Ramanand
dc.date.accessioned 2020-01-24T08:16:49Z
dc.date.available 2020-01-24T08:16:49Z
dc.date.issued 2019
dc.identifier.citation Barve, Gaurav Ramanand. 2019, Septin complex as a novel regulator of autophagosome biogenesis, Ph.D thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/handle/10572/2812
dc.description.abstract Eukaryotic cells achieve homeostasis inside the cells by maintaining the balance between synthesis and degradation of macromolecules. In particular, protein degradation is taken care of by two important systems viz. the Ubiquitin-Proteasome System (UPS) and Autophagy. Macroautophagy, herein autophagy is a major intracellular catabolic pathway that is indispensable for maintaining cellular homeostasis. This process is evolutionary conserved and is required not only for the degradation of unwanted and excess proteins but also for damaged organelles. In yeast, this process begins near vacuole called as pre-autophagosomal structure (PAS) at which a small membranous structure called as phagophore is formed. This phagophore then expands into double-membrane vesicles called autophagosomes that capture cytoplasmic cargoes and deliver them to vacuole or lysosomes for degradation. Based on the cargo that is captured, autophagy is divided into two types i.e. selective autophagy where a particular cargo such as peroxisomes (pexophagy), mitochondria (mitophagy) etc. are degraded while in general autophagy a portion of cytoplasm is degraded and thus the cargo is not specific (Johansen and Lamark 2011, Weidberg, et al. 2011). en_US
dc.language.iso English en_US
dc.publisher Jawaharlal Nehru Centre for Advanced Scientific Research
dc.rights © 2019 JNCASR
dc.subject Autophagosome biogenesis en_US
dc.title Septin complex as a novel regulator of autophagosome biogenesis en_US
dc.type Thesis en_US
dc.type.qualificationlevel Doctoral en_US
dc.type.qualificationname Ph.D. en_US
dc.publisher.department Molecular Biology and Genetics Unit (MBGU) en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account