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Elucidating the role of a multisubunit tethering complex-exocyst in autophagosome biogenesis

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dc.contributor.advisor Manjithaya, Ravi
dc.contributor.author Rajput, Sunaina Singh
dc.date.accessioned 2020-01-24T08:24:57Z
dc.date.available 2020-01-24T08:24:57Z
dc.date.issued 2019
dc.identifier.citation Rajput, Sunaina Singh. 2019, Elucidating the role of a multisubunit tethering complex-exocyst in autophagosome biogenesis, Ph.D thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/handle/10572/2813
dc.description.abstract Inside a cell, there is constant synthesis and degradation of cytosolic components such as various proteins, organelles, supramolecular assemblies including cytoskeleton, ribosomes and intracellular vesicles. This dynamic equilibrium is affected by cell intrinsic (organelle damage, signalling, etc.) and extrinsic (nutrient availability, temperature, pH, mitogens, pathogens, etc.) changes. Adaptation to such conditions is achieved by maintaining cellular homeostasis in which the rates of synthesis and degradation of components are modulated in order to maintain cellular health, thereby promoting its viability. In this context, proteolysis, the turnover of proteins, plays a role in regulating several key cellular events including cell cycle, receptor mediated endocytosis, signal transduction, adaptation to stress, etc. (Ciechanover, 2005). The two major pathways contributing in maintenance of cellular proteostasis are: 1) ubiquitin proteosome system (Driscoll and Goldberg, 1990), and 2) lysosomal mediated degradation (De Duve, 1963; De Duve et al., 1955). A major difference in mode of action of these two pathways is that individual proteins are degraded by proteasome (Finley, 2009) while lysosomal degradation aids in bulk protein degradation (Luzio et al., 2007). The smaller pore size of proteasome limits the degradation of larger cargo like protein complexes or aggregates (Finley, 2009). Such bulk cargo is degraded in lysosome (vacuoles in yeast) through a pathway known as autophagy. en_US
dc.language.iso English en_US
dc.publisher Jawaharlal Nehru Centre for Advanced Scientific Research en_US
dc.rights © 2019 JNCASR
dc.subject Autophagosome biogenesis en_US
dc.title Elucidating the role of a multisubunit tethering complex-exocyst in autophagosome biogenesis en_US
dc.type Thesis en_US
dc.type.qualificationlevel Doctoral en_US
dc.type.qualificationname Ph.D. en_US
dc.publisher.department Molecular Biology and Genetics Unit (MBGU) en_US


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