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Transcriptional Regulation by the Acetylation of Nonhistone Proteins in Humans – A New Target for Therapeutics

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dc.contributor.author Das, Chandrima
dc.contributor.author Kundu, Tapas K
dc.date.accessioned 2012-02-20T09:28:51Z
dc.date.available 2012-02-20T09:28:51Z
dc.date.issued 2005-03
dc.identifier 1521-6543 en_US
dc.identifier.citation IUBMB Life 57(3), 137-148 (2005) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/469
dc.description Restricted Access en_US
dc.description.abstract Gene expression from the dynamic chromatin template is regulated by certain key cellular players that cause post-translational modi. cations of both histones and nonhistone proteins. The acetyltransferases and deacetylases are two such key groups of enzymes that play crucial roles in maintaining the reversible acetylation status of histones and nonhistone proteins. Emerging evidence suggests that acetylation of nonhistone protein is equally important in the transcription regulation as the histone acetylation. Since dysfunction of HATs and HDACs leads to several diseases, aberrant acetylation of nonhistone protein is also associated with diseases. Small molecule modulators of these enzymes, which may help in maintaining the normal cellular acetylation status of these proteins, have important therapeutic implications. en_US
dc.description.uri http://dx.doi.org/10.1080/15216540500090629 en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis Inc en_US
dc.rights © 2005 IUBMB en_US
dc.subject transcription en_US
dc.subject acetyltransferase en_US
dc.subject deacetylase en_US
dc.subject nonhistone proteins en_US
dc.subject chromatin en_US
dc.subject activator en_US
dc.subject Histone Acetyltransferases en_US
dc.subject Chromatin Transcription en_US
dc.subject P300 en_US
dc.subject P53 en_US
dc.subject Binding en_US
dc.subject Represses en_US
dc.subject Pcaf en_US
dc.subject Activation en_US
dc.subject Alters en_US
dc.subject Domain en_US
dc.title Transcriptional Regulation by the Acetylation of Nonhistone Proteins in Humans – A New Target for Therapeutics en_US
dc.type Article en_US


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