Transcription Through Chromatin – Link to Diseases and Therapeutics

dc.contributor.author	A, Hari Kishore
dc.contributor.author	Iyengar, Sushma S
dc.contributor.author	Kundu, Tapas K
dc.date.accessioned	2012-03-05T09:47:32Z
dc.date.available	2012-03-05T09:47:32Z
dc.date.issued	2004-11
dc.identifier	1430-4171	en_US
dc.identifier.citation	Resonance 9(11), 23-38 (2004)	en_US
dc.identifier.uri	https://libjncir.jncasr.ac.in/xmlui/10572/547
dc.description	Open Access	en_US
dc.description.abstract	The expression of chromosomal genes is regulated by posttranslational modification of both histone and nonhistone chromatin proteins and ATP-dependent remodeling of chromatin. Dysfunction of the modification and remodeling machineries can lead to several diseases, which include cancer, cardiac hypertrophy, and asthma. Many genetic diseases can also lead to malfunction of the machinery. The enzymes responsible for chromatin organization are the new targets for therapeutics. Inhibitors and activators of histone acetyltransferases and inhibitors of histone deacetylases may serve as new generation drugs.	en_US
dc.description.uri	http://dx.doi.org/10.1007/BF02834970	en_US
dc.language.iso	en	en_US
dc.publisher	Springer	en_US
dc.rights	© 2004 Indian Academy Of Sciences	en_US
dc.subject	Cancer	en_US
dc.subject	chromatin therapy	en_US
dc.subject	cardiac hypertrophy	en_US
dc.subject	HIV	en_US
dc.subject	Rubin-stein-Taybi syndrome	en_US
dc.title	Transcription Through Chromatin – Link to Diseases and Therapeutics	en_US
dc.type	Article	en_US