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Human Histone Chaperone Nucleophosmin Enhances Acetylation-Dependent Chromatin Transcription

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dc.contributor.author Swaminathan, V
dc.contributor.author Kishore, A Hari
dc.contributor.author Febitha, K K
dc.contributor.author Kundu, Tapas K
dc.date.accessioned 2012-03-05T10:26:10Z
dc.date.available 2012-03-05T10:26:10Z
dc.date.issued 2005-09
dc.identifier 0270-7306 en_US
dc.identifier.citation Molecular And Cellular Biology 25(17), 7534-7545 (2005) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/548
dc.description Restricted Access en_US
dc.description.abstract Histone chaperones are a group of proteins that aid in the dynamic chromatin organization during different cellular processes. Here, we report that the human histone chaperone nucleophosmin interacts with the core histones H3, H2B, and H4 but that this histone interaction is not sufficient to confer the chaperone activity. Significantly, nucleophosmin enhances the acetylation-dependent chromatin transcription and it becomes acetylated both in vitro and in vivo. Acetylation of nucleophosmin and the core histones was found to be essential for the enhancement of chromatin transcription. The acetylated NPM1 not only shows an increased affinity toward acetylated histones but also shows enhanced histone transfer ability. Presumably, nucleophosmin disrupts the nucleosomal structure in an acetylation-dependent manner, resulting in the transcriptional activation. These results establish nucleophosmin (NPM1) as a human histone chaperone that becomes acetylated, resulting in the enhancement of chromatin transcription. en_US
dc.description.uri http://dx.doi.org/10.1128/MCB.25.17.7534-7545.2005 en_US
dc.language.iso en en_US
dc.publisher American Society for Microbiology en_US
dc.rights © 2005 American Society for Microbiology en_US
dc.subject Nucleolar Phosphoprotein B23 en_US
dc.subject Rna-Polymerase--II en_US
dc.subject In-Vitro en_US
dc.subject Acetyltransferase Complexes en_US
dc.subject P300-Mediated Acetylation en_US
dc.subject Nucleosomal Arrays en_US
dc.subject Crystal-Structure en_US
dc.subject Tumor- Suppressor en_US
dc.subject H2a-H2b Dimers en_US
dc.subject H2a/H2b Dimer en_US
dc.title Human Histone Chaperone Nucleophosmin Enhances Acetylation-Dependent Chromatin Transcription en_US
dc.type Article en_US


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