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Regulation of autophagic flux via dynamic trafficking of the SNARE Stx17: studies using a chemical biology approach

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dc.contributor.advisor Manjithaya, Ravi
dc.contributor.author Vats, Somya
dc.date.accessioned 2020-12-08T05:26:01Z
dc.date.available 2020-12-08T05:26:01Z
dc.date.issued 2019
dc.identifier.citation Vats, Somya. 2020, Regulation of autophagic flux via dynamic trafficking of the SNARE Stx17: studies using a chemical biology approach, Ph.D thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/handle/123456789/3064
dc.description Open access
dc.description.abstract Macroautophagy (herein autophagy) is a major intracellular pathway that is indispensable for maintaining cellular homeostasis. Autophagy has been evolutionarily conserved in organisms ranging from yeast to humans. The word autophagy, which is Latin for self-eating, was first coined by Christian de Duve (Deter et al., 1967). He identified autophagy as a process of self-cannibalization which involves sequestration of cellular components within double membrane structures called autophagosomes, which then fuse with lysosomes to form autolysosomes wherein complex macromolecules are degraded and recycled for cellular use. The rate at which dynamic turnover of cellular components occurs by the process of autophagy is called ‘autophagic flux’. Basal level of autophagy occurs in all cells and tissues, and is indispensable for maintaining cellular homeostasis by protein and organelle turnover (Mizushima et al., 2004; Musiwaro et al., 2013). Cellular stresses such as nutrient starvation, pathogen invasion, organellar damage and protein aggregation can increase levels of autophagy as an adaptive stress response. As autophagy is central to maintaining cellular homeostasis, dysfunctional autophagy has been attributed to a variety of major human disease such as cancer, neurodegeneration and cardiovascular diseases (Jiang and Mizushima, 2013). en_US
dc.language.iso English en_US
dc.publisher Jawaharlal Nehru Centre for Advanced Scientific Research en_US
dc.rights © 2019 JNCASR
dc.subject Autophagic flux en_US
dc.title Regulation of autophagic flux via dynamic trafficking of the SNARE Stx17: studies using a chemical biology approach en_US
dc.type Thesis en_US
dc.type.qualificationlevel Doctoral en_US
dc.type.qualificationname Ph.D. en_US
dc.publisher.department Molecular Biology and Genetics Unit (MBGU) en_US


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