Understanding conformational dynamics and kinetic behavior in plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase

Abstract

"This chapter is a survey of the available literature on 6-oxopurine phosphoribosyltransferases that includes structural and functional features, conformational changes involved in the process of catalysis, chemical mechanism of phosphoribosylation, metabolic significance of these enzymes, moonlighting functions of human hypoxanthine guanine phosphoribosyltransferase and strategies for inhibitor design against Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase. This survey is not fully exhaustive and covers only relevant published work."