Abstract:
Epilepsy is relatively common neurological disorder affecting 0.5-1% of population during their
lifetime (Hauser et al., 1993; Kaneko et al., 2002). Epilepsy is characterized by usually
unprovoked and recurrent seizures, which are consequence of intensive burst activity from
groups of neurons. Epileptic seizures are usually intermittent, self-limiting and occur with or
without loss of consciousness. Seizures are generalized when synchronized firing of neurons
involves the whole brain, or focal wherein seizure activity is limited to a specific brain region.
While final outcome of seizure results from many complex and interacting biological
phenomenon, abnormal cellular excitability and neuronal network defects are considered the two
major physiological elements underlying seizure activity of the brain.
