"Stem cells are unspecialized cells of embryonic, fetal or adult origin, which can give rise to the differentiated and mature cell types in the organism. Their potency to differentiate into different cell types depends ...

"Mitotic cell cycle ensures that the progeny cell receives a complete complement of the genome from the parent. Whenever growth supportive conditions exist, the cell senses and commits itself to the process of cell division ...

High fidelity chromosome segregation ensures proper inheritance of the genetic material, one of the most fundamental cellular processes. Chromosome segregation requires the linking of the chromosomes to a dynamic pulling ...

Epilepsy is a common neurological disorder characterized by recurrent epileptic seizures usually unprovoked by any immediately identifiable cause. One of the first descriptions of epileptic seizures can be traced back to ...

The vast eukaryotic genome is present within the confines of the nuclei as a compact nucleoprotein complex known as chromatin. Chromatin is fundamentally made up of repeating nucleosomal units which consists of 147 base ...

Macroautophagy (herein autophagy) is a major intracellular pathway that is indispensable for maintaining cellular homeostasis. Autophagy has been evolutionarily conserved in organisms ranging from yeast to humans. The word ...

The average human generates over a trillion mature blood cells each day, through a process called hematopoiesis. The bone marrow is the primary site of adult hematopoiesis with minor contributions from the spleen and ...

Eukaryotic cells achieve homeostasis inside the cells by maintaining the balance between synthesis and degradation of macromolecules. In particular, protein degradation is taken care of by two important systems viz. the ...

Post-translational modification (PTM) is covalent modification of proteins by addition of functional groups or even a protein, proteolytic cleavage of regulatory subunits or degradation of entire protein. Apart from ...

Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic ...